Senior Scientist / Principal Scientist, In Vivo Pharmacology, Oncology (Dual Posting)

Company: Healthcare Businesswomen's Association
Location: San Diego
Posted on: May 3, 2025

Job Description:

Job Description SummaryAbout the role:We are seeking a highly motivated and skilled Scientist specialized in oncology pharmacology to join our in vivo pharmacology team in the Oncology Disease Area at the Novartis BioMedical Research (BR) facility located in San Diego, CA. Our team is dedicated to the creation and development of innovative medicines to help cancer patients. We conceive, develop, validate, and employ pharmacological tools to evaluate the efficacy and safety of novel oncology drug candidates.Job DescriptionKey Responsibilities:

• As an experienced and skilled lab-based in vivo pharmacologist, you will develop and work on various preclinical tumor models that involve surgery procedures.
• You will be part of a fast-paced, integrated, and interactive research group exploring novel and innovative therapeutics for oncology programs.
• You will be responsible for generating and communicating pharmacology data to support the progression of oncology programs.
• Designing, conducting, analyzing, and reporting in vivo and ex vivo studies.
• In vivo work will include animal handling and techniques such as tumor inoculation, measurement, oral, SC, IP, and IV dosing, blood and tissue collection, and model development.
• Ex vivo work includes a range of cellular and biochemical assays, including multi-color flow cytometry, WES, ELISA, qPCR to help interpret in vivo observations.
• Employ good laboratory, data recording, and data documentation practices.
• Present results in lab, department, and project meetings.
• Collaborate effectively while working in a matrixed environment.Essential Requirements:
  • This position will be located at the San Diego, CA site and will not have the ability to be located remotely. This position will not require travel.
  • This is a dual posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience, and capabilities required to perform the role at the level the role has been offered (Senior Scientist / Principal Scientist).
  • Principal Scientist must be proficient with small rodent surgical techniques.
  • Principal Scientist must have hands-on experience developing complex in vivo cancer models such as orthotopic and GEMM models.
  • Bachelors or Masters in Pharmacology, Biochemistry, Bioengineering, Biology, Cell Biology, Molecular Biology, or a related life science area.
  • At least 5+ years hands-on experience and high proficiency in rodent handling procedures and in vivo skills including but not limited to dosing (IV, PO, SC, IP), tumor measurement, blood and tissue collection, necropsy.
  • Proficiency in cell culture, passaging, and harvesting cells.
  • Hands-on experience with ex vivo biological techniques and assays for PD analysis is a plus.
  • Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature.
  • Must be detail-oriented, punctual, reliable, and available on weekends when necessary.
  • Must be multi-tasking and able to handle multiple in vivo studies in parallel.
  • Computer literacy, especially proficiency with GraphPad Prism or similar systems, Excel, PowerPoint, and Word.Desirable Requirement:
    • Hands-on experience with ex vivo biological techniques and assays for PD analysis.
    • Senior Scientist: Proficiency with small rodent surgical techniques. Experience developing complex in vivo cancer models such as orthotopic and GEMM models.Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between: $93,800 and $174,200 / year for the Senior Scientist and $103,600 and $192,400 / year for the Principal Scientist; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.EEO Statement:The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.Accessibility and reasonable accommodations:The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Salary Range: $93,800.00 - $174,200.00Skills Desired: Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Drug Development, Drug Discovery, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory, Lifesciences, Machine Learning (Ml), Management, Medical Research, Molecular Biology.
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Keywords: Healthcare Businesswomen's Association, Calexico , Senior Scientist / Principal Scientist, In Vivo Pharmacology, Oncology (Dual Posting), Healthcare , San Diego, California